Obesity is associated with many diseases, including diabetes, heart disease and cancer. Many studies have confirmed the relationship between obesity and premature death, but few studies have analyzed the relationship between weight loss and mortality – is it safer to lose weight as soon as possible? Can early obesity lead to irreversible pathological changes?
On August 14, 2020, the Journal of the American Medical Association (JAMA) published a study showing that maintaining a normal weight as soon as possible is good for health. Reducing body mass index (BMI) from “obese” to “overweight” at the age of 25 could halve the risk of premature death.
A total of 24205 participants aged between 40 and 70 were included in the study. Their health status was assessed using data from the national health and nutrition examination. After controlling for gender, smoking and education, the researchers found that 12.4% of premature deaths were associated with obesity between early and middle adulthood. Participants who reduced BMI from “obese” to “overweight” in their youth had a 54% lower risk of death than those who remained in the “obese” range. If young people with BMI in the “obese” range at the age of 25 were able to reduce their BMI to the “overweight” range before middle age, 3.2% of the deaths in the study could be avoided.